Similarly, the biological implication of DRB1*15:02 in the protection from FMF is not clear, but non-competitive interaction between B*40:01 and DRB1*15:02 (Table 4) was distinctive and can provide a potential clue to the understanding of the contribution of protective HLA in the pathogenesis of FMF. Here, HLA-DRB1 is linked to familial Mediterranean fever.