The most upregulated proteins by SBP1 induction included DKK1 that inhibits WNT pathway [18], DHCR7 that controls cholesterol and Vitamin D synthesis [19], ANXA4 that inhibits NFkB pathway and IL-8 [20], and AGPAT5 that inhibits breast cancer cell proliferation [21]. The gene discussed is ANXA4; the disease is breast cancer.