However, the AXIN2 polymorphism rs2240308 was significantly associated with decreased cancer risk in Japanese under the dominant (CT+TT vs. CC: OR = 0.71, 95% CI: 0.52-1.97, P = 0.032) and allelic (T vs. C: OR = 0.77, 95% CI: 0.61-0.97, P = 0.024) models, but not in the homozygous (TT vs. CC: OR = 0.61, 95% CI: 0.36-1.01, P = 0.056), heterozygous (CT vs. CC: OR = 0.74, 95% CI: 0.53-1.03, P = 0.075) and recessive (TT vs. CT+CC: OR = 0.71, 95% CI: 0.44-1.15, P = 0.164) models. This evidence concerns the gene AXIN2 and cancer.