In cancer, Vehvilainen et al [23] studied the adhesion function of LTBP2 in melanoma cells, while we showed the pleiotropic anti-tumorigenic characteristics of LTBP2 in esophageal squamous cell carcinoma (ESCC) and NPC through comprehensive functional assay approaches [12,24]. Here, LTBP2 is linked to esophageal squamous cell carcinoma.