Since NFKBIA expression was diminished after p65 knockdown, we then screened a panel of NF-κB angiogenic-related target genes that include IL6, IL8, RANTES, MCP1, VEGF165, VEGF189, and Total VEGF. Taken together, these findings revealed that the inactivation of p65 in NPC tumor cells reduced the secretion of pro-angiogenic factors, resulting in inhibition of angiogenesis. This evidence concerns the gene RELA and nasopharyngeal carcinoma.