In our study, 50 of 146 cases were categorized into the GC subtype and the other 96 were the non-GC subtype based on Hans’ algorithm.Itis also interesting to note thatCD30 expression was predominant in Non-GCB DLBCLdescribed by Hans’ algorithm and correlated with the expression of bcl-2 protein in this study, which may contribute to explain the poor outcome.When CD30 expression, Non-GCB DLBCL and bcl-2 overexpression were included in the multivariate analysis by Cox modeling, CD30 expression didn’t retain its prognostic value (Data was not shown). This evidence concerns the gene TNFRSF8 and diffuse large B-cell lymphoma.