Regarding predictive factors for breast cancer, high EZH2 expression was significantly associated with the absence of estrogen receptor (positive vs. negative: OR 0.15, 95% CI: 0.11–0.20) and progesterone receptor (positive vs. negative: OR 0.30, 95% CI: 0.23–0.39) expression. The gene discussed is ESR1; the disease is breast carcinoma.