A number of the genes identified as discordant have been found to be mutated in the TCGA CRC dataset at frequencies >10% (e.g. SMAD4, ZNF831, ZNF217, HSP90AB1, TP53, SYNE1, SMAD2, TTN, MACF1, PREX1,FBXW7, CSMD3). The gene discussed is SMAD4; the disease is colorectal carcinoma.