IL10 and infection: Repeated percutaneous exposure to 4 doses (4x) of infective S. mansoni cercariae causes enhanced production of IL-10 by pinnae skin biopsies compared to those recovered from singly (1x) exposed pinnae (Fig 1A, p<0.001) and was accompanied by increased thickening of the skin at the site of infection when compared to skin exposed to a single dose of cercariae (Fig 1B, p<0.001).