TNNI3 and infection: To confirm this, we performed similar infections with clinical invasive disease isolates of serotype-1 pneumococci of a sequence type producing haemolytic PLY (ST300) and with a sequence type that produces a non-haemolytic PLY (ST306), and found that both cTnI and cTnT are elevated with ST300 but not with ST306 (Fig 1B).