We previously implicated the ETS family transcription factor ERG as a critical HSA21 gene in DS hematopoietic disease by demonstrating that specific reversion of Erg gene dosage to functional disomy, while the other ~103 orthologs remained trisomic, abrogated the myelo-megakaryocytic proliferation in Ts(1716)65Dn mice [20]. Here, ERG is linked to hematologic disorder.