By multivariate analysis, diabetes mellitus (p = 0.008, odds ratio (OR) = 2.841, 95% confident interval (CI): 0.985–8.193), and positive HBsAg (p<0.001, OR = 36.878, 95% CI: 11.770–115.547) were independent predictors of hepatitis B reactivation among AML patients. Here, PPIB is linked to acute myeloid leukemia.