CXCR2 and immunoglobulin G4-related sclerosing disease: Our findings, that the levels of expression of α-and β-defensin (Table 5) and of IL8RA and IL8RB (Table 3) were lower in PBMCs from IgG4-RD patients than from controls, suggest that functions of innate immunity may be impaired in IgG4-RD patients.