Five of these genes were decreased in IgG4-RD patients, including those encoding Charcot—Leyden crystal protein (CLC), desmocollin1 (DSC1), interleukin 8 receptors alpha (IL8RA) and beta (IL8RB), and leucine rich repeat neuronal 3 (LRRN3), whereas 16 were increased in IgG4-RD (Table 3). This evidence concerns the gene LRRN3 and immunoglobulin G4-related sclerosing disease.