Under this reconstructed MM environment, CD38+CD56+ MMC and CD138+ MMC populations were able to undergo up to 7 rounds of division in a 3-week culture.[11] In comparison to recent approaches by other investigators to recapitulate the MM microenvironment using biomimetic 3D scaffolds,[12–14] the significance of our approach is with its ability to provide perfusion. Here, NCAM1 is linked to Miyoshi myopathy.