In the HH group, the results for the atherosclerosis and venous thrombosis genes combined panels showed similar patterns of mutations’ expression as those of the healthy group with more pronounced profile of results: atherosclerosis genes [ACE (97.9%), β-fibrinogen (52.1%), HPA1 (28.5%), Apo E (14.0%) and Apo B (1.4%) (Fig 1A)] and venous thrombosis genes [FII (3.5%), FVL (13.9%), FVR2 (20.8%), FXIII (38.2%), MTHFR C677T (65.3%), MTHFR A1298C (68.8%), and PAI-1 (89.6%) (Fig 1B)]. The gene discussed is APOE; the disease is atherosclerosis.