Twelve gene mutations were screened: ACE(Del/Ins genotype), β-fibrinogen(-455 G>A), HPA-1(L33P(a/b) genotype), ApoB(R3500Q) and ApoE(E2/E3/E4 genotype) mainly involved in atherosclerosis and Prothrombin FII(G20210A), FVL(G1691A),FVR2(H1299R), FXIII(V34L), MTHFR(C677T and A1298C) and PAI-1(4G/5G genotype) mainly involved in venous thrombosis. The gene discussed is APOE; the disease is atherosclerosis.