FVL is the most common inherited form of thrombophilia; people who have the FVL mutation are at somewhat higher than average risk for a type of clot that forms in large veins in the legs (deep venous thrombosis) or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism) [23–25]. The gene discussed is F5; the disease is pulmonary embolism.