TNF and injury: Tang et al. had studied the anti-inflammatory effects of RDN on lipopolysaccharide-induced acute lung injury of rats7, they found that the anti-inflammatory effects of RDN was demonstrated to be preventing pulmonary neutrophil infiltration, lowering myeloperoxidase activity, TNF-α and iNOS gene expression by inhibiting NF-κB activity in LPS-induced acute lung injury.