Further, the redox state of HMGB1 and not only the amount might also impact on it, because not only nucleotides are the reason for therapy-induced tumor growth retardation; even in the presence of apyrase, multimodal treatment with zVAD-fmk significantly further retards tumor growth when compared with multimodal treatment only (Figure 5c). Here, HMGB1 is linked to neoplasm.