CXCL8 and psoriasis: Subsequently, in a phase II study in patients with recalcitrant psoriasis, apremilast 20 mg BID led to decreases in proinflammatory gene expression in the lesional skin, including IL-8, IL-12/IL-23p40, IL-17A, and IL-23p19, as well as inducible nitric oxide synthase [9].