Cancer cells experience a variety of stressful conditions like hypoxia, nutrient deprivation, acidosis, high interstitial pressure (1), and consequently, Hsp90 levels are found to be up-regulated in melanoma (2), breast cancer (3), gastric and pancreatic carcinoma (4, 5), ovarian and endometrial carcinoma (6, 7), etc. The increased level of Hsp90 causes chaperoning of the potentially dangerous oncogenic clients that are otherwise metastable. This evidence concerns the gene HSP90AA1 and melanoma.