Although c-Abl was initially shown to be present in pseudopodia protrusions, after stimulation with hepatocyte growth factor (HGF) in thyroid cancer cells (231), we demonstrated that the N-Cap-myristoyl tether may play a role in protein inhibition and also may direct the c-Abl protein to anchor in the membrane as an additional mechanism to stabilize this disordered segment, which may also be linked to early apoptotic signaling (217). This evidence concerns the gene HGF and thyroid cancer.