HGF and thyroid gland carcinoma: Although c-Abl was initially shown to be present in pseudopodia protrusions, after stimulation with hepatocyte growth factor (HGF) in thyroid cancer cells (231), we demonstrated that the N-Cap-myristoyl tether may play a role in protein inhibition and also may direct the c-Abl protein to anchor in the membrane as an additional mechanism to stabilize this disordered segment, which may also be linked to early apoptotic signaling (217).