Recently, a pragmatic, open label randomised trial has been published to evaluate, out of three classes of drug (levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI)) for initial treatment, which of these provides the most effective long-term control of symptoms and best quality of life for people with early Parkinson’s disease [73]. The gene discussed is MAOB; the disease is Parkinson disease.