Consistent with our findings, previous studies showed that CTGF caused EMT-like cell fate mediated by TAZ-TEAD complex [16, 30, 31] and CTGF expression could confer resistance to chemotherapeutic agents through ERK1/2-dependent Bcl-xL/cIAP1 up-regulation in mastocarcinoma [32] and AMPK-dependent NF-κB pathway in osteosarcoma [33]. Here, CCN2 is linked to osteosarcoma.