To the best of our knowledge, no research has addressed the role and mechanism of CrkII in salivary gland tumours to date; however, Rodrigues et al20have shown that CrkI/II knock down in breast cancer, a condition relatively similar to salivary glands carcinoma,17 could decrease cell spreading on extracellular matrix. The gene discussed is CRK; the disease is salivary gland carcinoma.