CRK and cancer: In addition to dysregulated Crk expression in some malignant neoplasms like glioblastoma and lung cancer,14,15 increased mRNA expression of CrkII genes was seen in more advanced stages of lung tumors with poor survival rates.16 CrkII has several important functions that involve regulation of the actin cytoskeleton, phagocytic entry of apoptotic cells, and pathogens into the host cells, as well as cell cycle, apoptosis, andmetabolism.12