Toda et al reported a relationship between salivary adiponectin and an increased risk of non-insulin-dependent diabetes mellitus and cardiovascular diseases.33 Micro et al introduced salivary leptin as a possible diagnostic marker for salivary gland tumors.34 In a study by Mamali et al, visfatin was identified in saliva but no significant relationship was found with its serum levels.35 It seems protein/polypeptide hormones cannot be identified in the saliva unless they are secreted by the salivary glands themselves. This evidence concerns the gene LEP and tumor of salivary gland.