Studies have shown that expression of visfatin increases in acute and chronic inflammatory conditions, including rheumatoid arthritis, sepsis,12acute pulmonary conditions,13 psoariasis,14 and type II diabetes mellitus.15 High serum levels of visfatin are considered a risk factor for cardiovascular diseases16,17 and an increase in the expression of visfatin by macrophages in unstable atherosclerotic lesions indicates the possible role of visfatin in destabilization of the atherosclerotic plaque.18 The gene discussed is NAMPT; the disease is rheumatoid arthritis.