In a cross-over study (for 6 month, n = 401, aged 40–70 yr and with a BMI > or = 25), consumption of 4 g CLA/d (4:1 ratio of 9- and 10-CLAs) did not influence aortic pulse wave velocity (marker of atherosclerosis), blood pressure, anthropometric characteristics, and concentrations of fasting lipid, glucose, insulin, and C-reactive protein (CRP), briefly it neither supported an anti-atherosclerotic effect nor an effect on CVD risk factors of 9- CLA [94]. This evidence concerns the gene CRP and atherosclerosis.