LGALS3 and benign thyroid gland neoplasm: In fact, certain normal thyroid follicles, nonneoplastic thyroid lesions (in particular thyroiditis), and benign thyroid tumors can exhibit focal or extensive staining for many of putative “thyroid cancer markers.” For instance, 31–55% of adenomatous hyperplasia could be positive for cytokeratin-19 or galectin-3.