By comparing NC with AD and AC sections, the presented study has found a gradual decrease of MUPCDH expression that progresses during the so-called “adenoma-carcinoma sequence.” However, this was not observed in a previous study on the role of mucin-like protocadherin in carcinoma pathogenesis where only cancer samples were compared with normal colonic mucosa sections [5]. The gene discussed is CDHR5; the disease is cancer.