For example, a lncRNA produced at the 5′ regulatory region of the cyclin D1 (CCND1) gene in response to genotoxic stress tethers and modulates the activity of the RNA-binding protein TLS (translocated in liposarcoma) which in turn inhibits the activity of the histone acetyltransferases CBP (CREB binding protein) and EP300, leading to CCND1 transcriptional repression (Wang et al., 2008). The gene discussed is CREBBP; the disease is liposarcoma.