E2F/PP-mediated transcriptional regulation of factors that potentiate differentiation has also been linked to tumorigenesis, where E2f1-mediated transcription of PPARγ and Fatty acid synthase (Fasn) drives proliferation and survival of medulloblastoma tumors (Bhatia et al., 2012; Bhasin et al., 2013), and activation of multiple Notch pathway genes by E2fs serves to limit tumor expansion in hepatocellular carcinoma (Viatour et al., 2011). Here, FASN is linked to hepatocellular carcinoma.