RENBP and influenza: In a single clinical trial that varied the doses of both MF59 (full, half, or quarter) and trivalent inactivated influenza vaccine (15 or 30 μg) in elderly subjects, Della Cioppa et al. found that more adjuvant tended to induce higher HAI titers but had no effect on the Ag-specific CD4 T cell response (30).