GRIN2A and systemic lupus erythematosus: For example, anti-double-stranded DNA (dsDNA) antibodies that cross-react with a linear epitope of the GluN2A and B subunits of the NMDAR have been found in 30–40% of patients with systemic lupus erythematodes (SLE) but whether these autoantibodies are responsible for neuropsychiatric symptoms of SLE remains a matter of controversy (4).