MICA and hepatocellular carcinoma: Recently, the GBM derived metabolite, lactate dehydrogenase isoform 5 (LDH5), was demonstrated to upregulate the NKG2D ligands MICA/B and ULBPs on monocytes from healthy individuals in vitro and on circulating macrophages from patient derived breast, prostate, and HCC as a further means to subvert NK cell surveillance (52).