Two other studies on patients with ITP and Kawasaki disease also showed no upregulation of FcγRIIb expression on monocytes after IVIg infusion, however, the validity of these results can be questioned as the antibody used to detect FcγRIIb in these studies binds to an intracellular epitope of the protein while no permeabilization protocol was applied (28, 29). This evidence concerns the gene FCGR2B and autoimmune thrombocytopenic purpura.