HIPK2 and neoplasm: HIPK2's pleotropic functions include serving as co-regulator of transcription factors, modulator of growth, development, morphogenesis and cell death, tumor suppressor, and regulator of response to DNA damage (Hofmann et al., 2001; D'Orazi et al., 2002; Link et al., 2007; Bitomsky and Hofmann, 2009; Calzado et al., 2014).