HDAC9 and systemic lupus erythematosus: Regna et al. showed that HDAC inhibition with ITF2357, a specific inhibitor of class I and II HDAC, reduces sera and urinary markers of lupus, and suppresses expression of several inflammatory cytokines (IL-1β, TNF-α, IL-6, and IFN-γ) and improves kidney histopathology (Regna et al., 2014).