In patients, some studies have reported an association between circulating sRAGE levels and brain infarct volume, stroke severity (Park et al., 2004; Yokota et al., 2009) and inflammatory status (Cui et al., 2013), others have suggested that sRAGE levels at onset may predict cognitive impairment after cerebral ischemia (Qian et al., 2012). The gene discussed is AGER; the disease is Cognitive impairment.