TLR4 and Cerebral ischemia: In addition, deficiency of TLR4 in young animals subjected to focal cerebral ischemia, promotes subventricular zone cell proliferation, increasing the number of the transit-amplifying cells (type C cells; prominin-1+/EGFR+/nestin- cells) at 24 and 48 h, of proliferating immature (BrdU+) cells at 7d and of neuroblast cells (type A cells; doublecortin+ cells) at 14d (Moraga et al., 2014).