Among these studies, Brooks et al. (2014) recently identified a panel of overlapping genes, significantly expressed within 3 h from stroke onset, including arginase1 (ARG1), carbonic anhydrase 4 (CA4), lymphocyte antigen 96 (LY96), matrix metalloproteinase 9 (MMP9), and S100 calcium binding protein A12 (S100A12). Here, CA4 is linked to stroke disorder.