Altogether, PPAR-γ appears to drive positive effects on oxidative metabolism, adipogenesis and tissue remodeling in response to obesity, in part related to M2a polarization, but it still allows chronic low-grade macrophage inflammation, due to persistence of CD11c+ IL-12p40+M1-like profile and paucity of regulatory CD163+ IL-10+ M2c cells. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.