Expression levels of multiple genes encoding for cytokines or cytokine receptors over-expressed in tumor cells or ascites fluid, such as CXCL1, CXCL2, CXCL3, IL8, IL6, IL6R, and CXCR4 [49–51] were reduced in OV3/COX1KD cells (Figure 4A). This evidence concerns the gene CXCL8 and neoplasm.