Moreover, USP17 was differentially expressed during the cell cycle, and it was discovered that USP17-knockdown caused a G1 cell cycle block and inhibited the proliferation of tumor-derived cell lines by attenuating GTPase signaling, and that USP17 is tightly regulated during cell division and its expression is necessary to coordinate cell cycle progression [30, 31]. Here, USP17L2 is linked to neoplasm.