BRAF and melanoma: Since melanoma can be divided into three mutually exclusive genetic subsets: BRAF mutant melanoma, NRAS mutant melanoma and melanoma of wild type at both loci [40], to confirm the generality of this finding, beside two BRAF mutant melanoma cell lines A375 and A2058, NRAS mutant melanoma cell line sk-mel-2 and wild type NRAS and BRAF melanoma cell line MeWo with constant c-Met activation [12] were also used.