In line with this, Trf1Δ/ΔK-Ras+/G12Vp53−/− carcinomas presented an increased number of giant nuclei indicative of endoreduplication, as well as increased anaphase bridges, compared to Trf1+/+K-Ras+/G12Vp53−/− carcinomas (Fig4C–E). Here, KRAS is linked to carcinoma.