The androgen deprivation therapy (ADT), which suppresses or reduces androgens binding to the androgen receptor (AR), is a well-known treatment strategy for advanced, recurrent and even metastatic prostate cancer; however, the long term therapeutic outcomes of ADT on prostate cancer remain uncertain, and are associated with considerable known adverse effects that affect the quality of life in prostate cancer patients [3]. The gene discussed is AR; the disease is metastatic prostate carcinoma.