The intensity of PRR11 staining increased with the progression of HC: 0.12±0.30 in normal bile duct tissues, 0.50±0.43 in intraepithelial neoplasia, 0.97±1.15 in stage I/II, 1.58±0.98 in stage III/IV and 2.83±0.28 in lymph node metastases (Figure 2D and 2E). Here, PRR11 is linked to intraepithelial neoplasia.