RIF1 and cancer: For example, the transmembrane protein HID1 that was observed as a major hubgene in the RNAseq GRN is reported to be downregulated in multiple cancers [53]; FER1L4 is a lncRNA reported to be prominently downregulated in gastric cancer [54], TTLL3 is described as a candidate cancer gene [55], RIF1 has been described to have anti-apoptotic properties in DNA repair [56] and SBNO1 (strawberry notch homolog 1) was reported in lung cancer [57].