PIM3 and familial pancreatic carcinoma: In line with previous reports [29, 30], we found that the AKT/β-catenin signaling was activated in gemcitabine-resistant pancreatic cancer cells, and that overexpression of miR-33a reversed the increased expression of β-catenin by inhibiting Pim-3/AKT/β-catenin signaling (Figure 6G).