CDK6 and familial pancreatic carcinoma: Although a previous study showed that miR-33a-mediated downregulation of cyclin-dependent kinase 6 (CDK6) reduces cell proliferation [20, 24], we found that overexpression of miR-33a did not downregulate CDK6 protein in SW1990 or MiaPaca-2 cells (Figure 6A), indicating that the effects on Pim-3 expression are specific to pancreatic cancer cells that we examined.