Clinically, up-regulation of EGFR can be detected in NPC patient biopsies [31], as PTPRG can induce dephosphorylation of EGFR and, thus, the downstream PI3K/Akt signaling pathway; this further supports the critical tumor suppressive role of PTPRG in NPC. This evidence concerns the gene AKT1 and nasopharyngeal carcinoma.