The role of Akt inhibition on invasion suppression of cancer cells was also investigated; significant suppression of invasion was observed with both HONE1 and HK1 cell lines expressing both Akt knockdown oligonucleotides (32.9% and 22.74% for AKT984 and AKT1793 in HONE1, respectively, and 58.5% and 60.7% for AKT984 and AKT1793 in HK1, respectively) (Figure 4B). The gene discussed is AKT1; the disease is cancer.