Leverson et al have further characterized the most potent of the compounds, A-1210477: it binds selectively to MCL-1 with an affinity of 0.45 nM, disrupts BIM/MCL-1 complexes in living cells, induces the hallmarks of mitochondrial apoptosis in MCL-1-dependent cancer cells and synergizes with navitoclax to induce apoptosis in various malignant cell lines [48]. Here, MCL1 is linked to cancer.