BM-957 is another ABT-737 derivative (a diphenyl-pyrrole-carboxamide scaffold linked to the nitrobenzene sulfonamide half of ABT-737): it also binds to BCL-2 and BCL-XL with sub-nM affinity, induces caspase 3-dependent apoptosis in tumor cell lines and causes tumor regression in xenograft models [38]. The gene discussed is BCL2; the disease is neoplasm.