NCOA3 and gastric cancer: In this study, knocking down AIB1 expression in gastric cancer cells significantly reduced the expression of β-catenin and its target genes, as supported by two previous studies that AIB1 directly interacted with the general transcriptional cointegrator CBP/p300 through CBP-interaction domain (CID) in the C-terminal region [44], and interaction of CBP with β-catenin can activate gene expression [45].