For this pair CCND1 specifically demonstrated a high amplification in the primary cancer (1.32 log2 ratio amplification spanning 1.5Mb sequence and 13 genes); a similar amplified region containing CCND1 was more focused and of increased amplitude in the metastatic tumor (a 752,615 base pair, 2.2 log2 ratio amplification comprising only 6 genes, including CCND1, MRGPRD, MRGPRF, TPCN2, MYEOV and ORAOV1). Here, LTO1 is linked to cancer.