GPC3 and neoplasm: In fact, these are well known indicators for poor prognosis and early tumor recurrence in patients with HCC, for instance, glypican 3 [22], MicroRNA-29 [23], hyaluronic acid [24], Ski-interacting protein [25], interleukin-6 [26], VEGFR2 [27], IL-17 and IL-17RE [28], G2890 N-glycan [29], GGT [30] and miR-24-3p [31].