Several tumor markers for HCC, such as alpha fetoprotein (AFP) [5], retinol-binding protein 4 [6], desgamma-carboxy prothrombin time (DCP) and AFP-leptin 3 (AFP-L3) [7], have been identified as potential candidates to evaluate the prognosis of patients with HCC. The gene discussed is AFP; the disease is hepatocellular carcinoma.