Interestingly, further analysis of FASN, p62 and TIP47 staining in orthotopic CRCs using confocal microscopy revealed a high degree of spectral overlap between FASN and p62, and FASN and TIP47, suggesting that these proteins may reside in close proximity or interact in CRC cells (Supplemental Figure 4D). The gene discussed is PLIN3; the disease is colorectal carcinoma.